Hume Research Laboratory
Patrick S. Hume, MD, PhD
Assistant Professor
Division of Pulmonary, Critical Care and Sleep Medicine
Department of Medicine
National Jewish Health
Denver, Colorado, USA
Macrophage Biology
Numerous leukocyte populations in the human lung work together to defend the body from diseases and repair the lung after injuries caused from environmental exposures like smoke inhalation. Billions of lung macrophages are distributed throughout healthy lung tissue - standing ready to initiate the immune response
Defining the location of macrophages in the human lung
Where do macrophages actually reside in the lungs? See our publication in the American Journal of Respiratory & Critical Care Medicine which identified the location of billions of macrophages in human lungs using advanced microscopy
How does the local tissue environment influence macrophage function?
The Hume Lab utilizes advanced microscopy to visualize macrophages in the human lung. Our focus is to unravel roles of myeloid cells in the development of chronic diseases including COPD
Spatial Heterogeneity
The location of lung leukocyte subtypes varies based on specific tissue layer. Does their function vary as well? Stay tuned!
Macrophages in Smokers
Cigarette smoking alters and reduced macrophage function. See our recent publication in the American Journal of Physiology - Lung Cellular and Molecular Physiology investigating the role of hypoxia signaling in macrophages during smoke exposure.
Recent Lab News:
Spring 2023
We'll be sharing our recent progress with human lung compartment-specific single cell RNA sequencing at several upcoming conferences including the 2023 Keystone Conference on Myeloid biology in Snowbird, UT (April 2023), the annual meeting of the American Thoracic Society in Washington DC (May 2023) and the Vermont Stem Cells and Bioengineering Conference in Burlington, VT (July 2023).
Fall / Winter 2022:
We're making continued progress analyzing our human compartment-specific single cell RNA Sequencing data
Several of our group's collaborations are nearing publications, stay tuned!
Summer 2022:
We're please to announce our recent publication in the American Journal of Physiology - Lung Cellular and Molecular Physiology investigating the role of (or lack there of) of leukocyte HIF-1a signaling in the development of murine emphysema
Congratulations to undergraduate researcher extraordinaire Katelyn Lyn-Kew on her successful summer research project in the lab. Good luck finishing your final year at the University of Washington and next stop, Med school!
We are grateful to have had the opportunity to present our work in progress at the 2022 Thomas L. Petty Aspen Lung Conference
Spring 2022:
We're thrilled to welcome Jennifer Driscoll to the lab as our new full time technician. Let the tissue staining begin!
We presented our recent work at the annual meeting of the American Thoracic Society in San Francisco
