Hume Research Laboratory

Patrick S. Hume, MD, PhD

Assistant Professor

Division of Pulmonary, Critical Care and Sleep Medicine

Department of Medicine

National Jewish Health

Denver, Colorado, USA

Macrophage Biology

Numerous leukocyte populations in the human lung work together to defend the body from diseases and repair the lung after injuries caused from environmental exposures like smoke inhalation. Billions of lung macrophages are distributed throughout healthy lung tissue - standing ready to initiate the immune response

Defining the location of macrophages in the human lung

Where do macrophages actually reside in the lungs? See our publication in the American Journal of Respiratory & Critical Care Medicine which identified the location of billions of macrophages in human lungs using advanced microscopy

How does the local tissue environment influence macrophage function?

The Hume Lab utilizes advanced microscopy to visualize macrophages in the human lung. Our focus is to unravel roles of myeloid cells in the development of chronic diseases including COPD

Spatial Heterogeneity

The location of lung leukocyte subtypes varies based on specific tissue layer. Does their function vary as well? Stay tuned!

Macrophages in Smokers

Cigarette smoking alters and reduced macrophage function. See our recent publication in the American Journal  of Physiology - Lung Cellular and Molecular Physiology investigating the role of hypoxia signaling in macrophages during smoke exposure.

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